AZACITIDINE PACKAGE INSERT PDF

MyAza (Azacitidine for Injection) contains Azacitidine IP, which is a pyrimidine The finished product is supplied in a sterile form for reconstitution as a. No formal clinical drug interaction studies with azacitidine have been conducted. The printed package leaflet of the medicinal product must state the name. Drug: Azacitidine – Vidaza® Oncology – Intravenous Dilution Data. (, ) – [ SEE PACKAGE INSERT FOR ADDITIONAL DETAILS]].

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Doses greater than 4 mL should be divided equally into 2 syringes and injected into 2 separate sites. Disclaimer The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment.

Vigorously shake or roll the vial until a uniform suspension is achieved. Treatment may be continued as long as the patient continues to benefit. If it comes in contact with mucous membranes, flush thoroughly with water.

This medication is classified as an azacitiine and a “demethylation” agent.

The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment. A pyrimidine nucleoside analog that inhibits RNA and Pakcage synthesis Used for the treatment of patients with certain myelodysplastic syndrome subtypes Contraindicated in patients with advanced malignant hepatic tumors or hypersensitivity to mannitol.

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Counsel patients about the reproductive risk and contraception requirements during azacitidine treatment. QOL assessment found significant major advantages in physical function, symptoms, and psychological state for patients initially treated with azacitidine.

This suppressed reactivity can persist for insrt to 6 weeks after treatment discontinuation.

We strongly encourage you to talk with your health care professional about your specific medical condition and treatments. Non-proliferating cells are relatively insensitive to azacitidine. Elevated BUN or serum creatinine level during therapy: Your email has been sent. Send the page ” ” to a friend, azaacitidine, colleague or yourself.

Chemotherapy and biotherapy guidelines and recommendations for practice 2nd. Once incorporated into tRNA, azacitidine inhibits tRNA methyltransferases and interferes with tRNA methylation and processing, which leads to inhibition of azavitidine synthesis. Under refrigeration 2 to 8 degrees C or 36 to 46 szacitidine Fthe solution in the vial or a syringe is stable for up to 8 hours when reconstituted with Sterile Water for injection that was not refrigerated or for up to 22 hours when reconstituted with Sterile Water for injection that was refrigerated.

Advise pregnant women of the potential risk to the fetus. Immediately prior to administration, invert the syringe 2 or 3 times and vigorously roll the syringe between the palms until a uniform, cloudy suspension is achieved. Administer the total dose over a period of 10 — 40 minutes. Because elderly patients are more likely to have decreased renal jnsert, care should be taken in dose selection, and it may be useful to monitor renal function [see Warnings and Precautions 5.

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An in azaccitidine study of azacitidine incubation in human liver fractions indicated that azacitidine may be metabolized by the liver. Instructions for Intravenous Administration. Do not store for later use.

Vidaza (azacitidine) dose, indications, adverse effects, interactions from

Related Drug Information Drug Summary. Azacitidine is an anti-cancer “antineoplastic” or “cytotoxic” chemotherapy drug. Published studies indicate that urinary excretion is the primary route of elimination of azacitidine and its metabolites.

Non-proliferating cells are relatively insensitive to azacitidine.

Azacitidine

Recipient’s Email Separate multiple email address with a comma Please enter valid email address Recipient’s email is required. The reconstituted product may be kept in azacitdiine vial or drawn into a syringe.

Preparation for Immediate Subcutaneous Administration: The solution should be clear. Azacitidine also belongs to the category of chemotherapy called antimetabolites.